肾脏病与透析肾移植杂志 ›› 2019, Vol. 28 ›› Issue (2): 156-160.DOI: 10.3969/j.issn.1006-298X.2019.02.013
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组蛋白去乙酰化酶（HDAC）是一类去除组蛋白赖氨酸残基乙酰基团的酶家族，通过调控组蛋白及非组蛋白的乙酰化水平而影响下游的基因表达。近年来随着对HDAC家族各亚型的研究深入，发现其在足细胞损伤等多种肾脏病变中发挥重要作用。本文就目前HDAC与足细胞损伤之间关系的研究进展作一综述。
关键词: 组蛋白去乙酰化酶, 足细胞损伤, miRNA, 糖尿病肾病
Abstract:
Histone deacetylases (HDAC) are a family of enzymes that remove acetyl groups from lysine amino acid of histone and nonhistone proteins.HDAC epigenetic regulated gene expression and affect cellular functions.Recent studies point to a critical roles for histone acetylation and deacetylation in the pathogenesis of kidney disease,including podocyte injury.This article reviews the current understanding of roles for individual HDAC isozymes in podocyte injury.
Key words: histone deacetylases, podocyte injury, miRNA, diabetic nephropathy
李知，侯庆，陈朝红，等. 组蛋白去乙酰化酶与足细胞损伤[J]. 肾脏病与透析肾移植杂志, 2019, 28(2): 156-160.
LI Zhi,HOU Qing,CHEN Zhaohong,et al. Histon deacetylase and podocyte injury[J]. Chinese Journal of Nephrology, Dialysis & Transplantation, 2019, 28(2): 156-160.
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http://www.njcndt.com/CN/Y2019/V28/I2/156
