关键词: 血液透析, 人类免疫缺陷病毒, 慢性肾脏病矿物质与骨异常, 血钙, 血磷

Abstract: Objective:To observe the clinical characteristics of chronic kidney disease⁃mineral and bone disorder (CKD⁃MBD) in maintenance hemodialysis (MHD) patients complicated with human immunodeficiency virus (HIV) infection. Methods:Collect general information and laboratory tests of MHD patients with and without HIV infection, and compare the levels and compliance rates of blood calcium, phosphorus, and intact parathyroid hormone (iPTH) between the two groups using rank sum test or Fisher􀆳s exact probability method. Results:A total of 13 MHD patients with HIV infection and 13 non-HIV infected MHD patients matched in age and gender were enrolled, with 12 males in each group (92.3%). The average age is 47 years old. The fluctuation range of blood calcium and phosphorus in MHD patients in the HIV infected group is greater than that in the non-HIV infected group. The compliance rates of blood calcium, blood phosphorus, and iPTH in HIV infected patients were 46.2%, 38.5%, and 30.8%, respectively, while those in non-HIV infected patients were 76.9%, 46.2%, and 46.2%, respectively. The comparison of the compliance rates of the above three indicators between the two groups showed that the P⁃values were 0.226, 1.000, and 0.878, respectively, with no statistically significant differences. In the non-HIV infected group, one patient (7.7%) underwent parathyroidectomy and two patients (15.4%) were treated with cinacalcet, while none of the patients in the HIV infected group required either treatment. Conclusion:Blood calcium and phosphorus levels vary greatly among hemodialysis patients with HIV infection, and secondary hyperparathyroidism is not severe. Individualization is particularly important in the long⁃term management of such patients.

Key words: hemodialysis, human immunodeficiency virus, chronic kidney disease?mineral and bone disorder, calcium, phosphorus