关键词: font-family:Inter, -apple-system, BlinkMacSystemFont, ", font-size:16px, background-color:#F9FAFB, ">整合素受体, 肾小球肾炎, 肾小管间质疾病, 糖尿病肾病, 多囊肾病

Abstract: Integrins, functioning as heterodimeric transmembrane glycoprotein complexes, exert pivotal regulatory control over pathophysiological processes including cellular adhesion, proliferation, apoptosis, and malignant tumor invasion/metastasis through orchestrating multidimensional biological interactions among cell-cell, cell-extracellular matrix (ECM), and cell-pathogen interfaces. Emerging evidence demonstrates that aberrant expression profiles and functional impairments within the integrin receptor superfamily are mechanistically implicated in the pathogenesis of diverse renal pathologies, encompassing glomerulonephritis, tubulointerstitial lesions, renovascular disorders, diabetic nephropathy, and polycystic kidney disease. This review synthesizes cutting-edge research advancements to methodically delineate the molecular architecture, subtype classification paradigms, conformational activation regulatory mechanisms of integrin receptors, and their disease-specific operational modalities across heterogeneous renal pathologies. Particular emphasis is placed on elucidating their critical involvement in renal microenvironmental modulation via sophisticated signal transduction networks, while identifying prospective therapeutic targets. These insights aim to establish a conceptual framework for deciphering molecular pathogenesis and advancing innovative therapeutic strategies for renal-associated disorders.

Key words: font-family:Inter, -apple-system, BlinkMacSystemFont, ", font-size:16px, background-color:#F9FAFB, ">integrin receptors, glomerulonephritis, tubulointerstitial diseases, diabetic nephropathy, polycystic kidney disease