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Abstract: Ｏｂｊｅｃｔｉｖｅ：To investigate the effect and mechanism of caloric restriction on the progression of renal ischemic fibrosis.
Ｍｅｔｈｏｄｏｌｏｇｙ：Unilateral renal ischemia reperfusion fibrosis model was established in mice. They were randomly divided into shamoperated group, shamoperated caloric restriction group, ischemiareperfusion group, and ischemiareperfusion caloric restriction group. On the third day after surgery, the mice in the caloric restriction group were fed for a limited time, and the daily dietary intake was 66％ of the normal level. The mice in the control group continued to eat freely after ischemic surgery, and all groups drank freely. The state of rats in each group was observed and recorded during the diet. The right kidney was excised 20 days after reperfusion, and blood was collected 24 hours later and kidney tissue was retained. Serum creatinine, urea nitrogen and pathological examination were detected for experimental analysis.
Ｒｅｓｕｌｔｓ：Caloric restriction aggravated renal ischemic fibrosis. Caloric restriction enhances the autophagy activity after renal ischemia. The effect of caloric restriction on renal ischemic fibrosis was significantly weakened after autophagy was inhibited.
Ｃｏｎｃｌｕｓｉｏｎ：Caloric restriction after renal ischemia can aggravate renal fibrosis by activating autophagy.

Key words: caloric restriction, ischemia-reperfusion injury, renal fibrosis, autophagy chronic kidney disease