维持性血液透析患者肌少症及肌少性肥胖的相关因素

doi:10.3969/j.issn.1006298X.2021.02.003

肾脏病与透析肾移植杂志 ›› 2021, Vol. 30 ›› Issue (2): 113-118.DOI: 10.3969/j.issn.1006298X.2021.02.003

维持性血液透析患者肌少症及肌少性肥胖的相关因素

出版日期:2021-04-28 发布日期:2021-06-06

Risk factors of sarcopenia and sarcopenic obesity in maintenance hemodialysis patients

Online:2021-04-28 Published:2021-06-06

摘要/Abstract

摘要： 目的：评估维持性血液透析(MHD)患者肌少症及肌少性肥胖的患病率,并分析可能导致肌少症的危险因素。
方法：选取2019年10月至2020年3月山西医科大学第二医院的120例MHD患者为研究对象。采用亚洲肌少症诊断标准,筛查肌少症患者,计算其患病率。比较肌少症组和非肌少症组临床指标的差异,Logistic回归分析肌少症的危险因素。再根据体脂百分比(男性≥25％,女性≥35％),将患者分为肌少性肥胖组与肌少性非肥胖组,比较两组营养、运动等相关指标。
结果：(1)MHD患者肌少症的患病率为3080％,随年龄增加肌少症的患病率增加,肌少性肥胖患病率为1500％。(2)MHD肌少症患者年龄明显高于非肌少症患者,其握力、干体重、舒张压、脱水量、血清白蛋白、透前β2微球蛋白、透前血清肌酐、血清铁、总铁结合力、体力活动、平均每日蛋白质摄入量、平均每日能量摄入量均明显低于非肌少症患者(P<005)。采用Logistic回归结果显示,体力活动少、平均每日蛋白质摄入量<09 g／(kg·d)、握力弱、干体重轻是MHD患者发生肌少症的危险因素。
结论：MHD患者肌少症、肌少性肥胖患病率较高。体力活动少、平均每日蛋白质摄入量<09 g／(kg·d)、握力弱、干体重轻是MHD患者发生肌少症的危险因素。

关键词: 维持性血液透析, 肌少症, 肌少性肥胖, 人体成分, 危险因素

Abstract: Ｏｂｊｅｃｔｉｖｅ：To assess prevalence of sarcopenia and sarcopenia obesity in maintenance hemodialysis(MHD) patients,and analyze the risk factors.
Ｍｅｔｈｏｄｏｌｏｇｙ：One hundred and twenty patients who received MHD treatment in the Second Hospital of Shanxi Medical University from October 2019 to March 2020 were enrolled.Asian sarcopenia diagnostic criteria were used to screen patients.According to the percentage of body fat (male≥25％,female≥35％),patients with sarcopenia were divided into sarcopenia obesity group and sarcopenia nonobesity group,the nutrition and exercis indicators were compared.
Ｒｅｓｕｌｔｓ：In MHD patients,the prevalence of sarcopenia was 3080％,positiuely related with age,the prevalence of sarcopenia obesity was 1500％.The age of patients with sarcopenia was significantly higher than that of patients without sarcopenia.Their handgrip strength,dry weight,diastolic blood pressure,dehydration rate,serum albumin,β2 microglobulin,predialysis serum creatinine,blood iron,the total ironbinding capacity,physical activity,average daily protein intake,and average daily energy intake were significantly lower than those of patients without sarcopenia (P<005).Logistic regression showed that low physical activity,average daily protein intake <09 g／(kg·d),weak handgrip strength,and light dry weight were risk factors for sarcopenia in maintenance hemodialysis patients.
Ｃｏｎｃｌｕｓｉｏｎ：
Low physical activity,average daily protein intake,weak handgrip strength,and light dry weight were risk factors for sarcopenia in MHD patients.

Key words: maintenance hemodialysis, sarcopenia, sarcopenia obesity, body composition, risk factors

秦姣, 刘文霞, 苏佳欣, 王利华, 李静. 维持性血液透析患者肌少症及肌少性肥胖的相关因素[J]. 肾脏病与透析肾移植杂志, 2021, 30(2): 113-118.

QIN Jiao, LIU Wenxia, SU Jiaxin, WANG Lihua, LI Jing. Risk factors of sarcopenia and sarcopenic obesity in maintenance hemodialysis patients[J]. Chinese Journal of Nephrology, Dialysis & Transplantation, 2021, 30(2): 113-118.

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ISSN 1006-298X CN 32-1425/R

维持性血液透析患者肌少症及肌少性肥胖的相关因素

Risk factors of sarcopenia and sarcopenic obesity in maintenance hemodialysis patients

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