Abstract: Klotho is mainly derived from the kidney. Previous studies mainly focused on the role of Klotho in chronic kidney diseasemineral and bone disorder. Recently researches had found that serum and urine Klotho changed significantly in early stage of acute kidney injury (AKI),the sensitivity and specificity of Klotho for early detecting AKI are higher than traditional biomarkers (serum creatinine,cystatin C,etc.),which has important clinical significance in diagnosis of AKI. Klotho could serve as a novel biomarker of AKI. Mean while,Klotho has diversity of functions including suppression of inflammation,apoptosis and cell senescence,decreasing oxidative stress. Klotho plays a role in renal protection in AKI,which would be a new direction of AKI treatment. We reviewed recent studies about the role of Klotho in diagnosis and treatments of AKI.

Key words: Klotho, acute kidney injury, diagnosis, therapy