Abstract: An 81yearsold male was characterized by nephrotic syndrome with  acute kidney injury(AKI) stage 3,positive  serum antinuclear antibody (ANA) and antihistone antibody (AHA) with high titer,normal serum complement C3 and C4,as well as negative  serum antiphosphatase A2 receptor (PLA2R) antibody,which were arisen abruptly after taking aceclofenac for 3 months (cumulative dose 96g). Renal pathology suggested PLA2R negative membranous nephropathy with moderate acute tubulointerstitial injury. The patient′s condition was relieved rapidly after glucocorticoid and support treatments,as well as ANA and AHA turned negative simultaneously. The final diagnosis was aceclofenac associated lupus and AKI.