关键词: 膜性肾病, 新月体, 临床病理

Abstract:

Ｏｂｊｅｃｔｉｖｅ：To investigate the clinicopathologic characteristics in membranous nephropathy (MN) patients with crescent formation.
Ｍｅｔｈｏｄｏｌｏｇｙ：Seventy five patients who were biopsyproven idiopathic MN with crescent formation in the absence of systemic autoimmune disease or other etiologic factors were enrolled into this retrospective study. According to whether or not histological crescent formation they were divided into two groups: 15 patients with crescent formation and 60 patients without crescents as controls. The clinicopathological and laboratory data of the two groups were collected．Treatment and followup of patients with crescentic MN were analyzed.
Ｒｅｓｕｌｔｓ：Significantly higher serum creatinine and percentages of renal failure in the MN with crescents group than that in the controls, with especially severe proteinuria and decreased hemoglobin （P<005）. Remarkably higher rates of interstitial fibrosis /tubular atrophy ( IFTA) and the infiltration of inflammatory cell in the MN with crescents group than those in the controls （P<005）. The stage of the crescents MN group is posterior to that of the controls （P<005）.
Ｃｏｎｃｌｕｓｉｏｎ：Membranous nephropathy with crescents is a distinctive combination, which presents heavy clinical manifestations and serious pathological changes. Longterm followup should be conducted to exclude further secondary  etiologic factors.

Key words: membranous nephropathy, crescent, clinicopathological