关键词: 肾移植, 移植肾肾小球病, 临床病理, 治疗, 预后

Abstract: Transplant glomerulopathy (TG) is a group of disorders that are characterized histopathologically by glomerular capillary loop duplication with pauciimmunocomplex deposition.Cardinal clinical symptoms of TG included proteinuria,serum creatinine elevation and hypertension.It is the leading cause of longterm allograft failure.Although chronic and repetitive endothelial injury is conceived to be the contributing factor,the exact pathomechanism of TG remains elusive.Chronic active antibodymediated rejection (cABMR) is the predominant etiology for TG,with alloantibody,T cellmediated rejection (TCMR),thrombotic microangiopathy (TMA) and hepatitis C virus (HCV) infection have all been reported to cause TG.Early intervention may obtain a more desirable result for TG that predominantly targets prevention.

Key words: renal transplantation,transplant glomerulopathy,clinicopathology spectra,treatment  , prognosis