关键词: 慢性肾脏病, 半乳糖凝集素-3, 心血管事件, 风险

Abstract:

ABSTRACT Objective: To investigate the relationship between serum Galectin-3(Gal-3) levels and the risk of cardiovascular events and left ventricular geometry remodeling in chronic kidney disease (CKD)patients. Methodology: From Dec. 2013 to Mar. 2015, the patients aged 16-65 years with baseline CKD stages 2 to 5 were investigated, and a total of 436 CKD patients were enrolled in the final analysis. They were male 272 and female 164 with an average age of 42.3±15.8years old. Baseline clinical characteristics were obtained. Serum uric acid, creatinine, albumin and C-reactive protein were measured by standard laboratory techniques. Glomerular filtration rate (GFR) was calculated using the CKD-EPI formula. Serum Gal-3 levels were measured by using enzyme linked immunosorbent assay (ELISA). N-terminal pro-hormone of brain natriuretic peptide (NT-proBNP) (Normal values 0–53.1pmol/L) and troponin T (TnT) was measured by an electrochemiluminescence immunoassay (ECLIA). All patients were examined by transthoracic echocardiography to measure the diameter of the left ventricle. Left ventriclar mass index (LVMI) and relative wall thickness (RWT) were obtained by chocardiography. Coronary artery calcification score (CACS) was determined by Spiral computed tomographe coronary angiography. Lateral luvbar X-ray score of the abdominal aorta was used to determine aortic artery calcification (AAC). Results: Serum Gal-3 concentrations were significantly highly in CKD stage 2 patients than that of control group [22.47(16.18, 29.40)ng/mlvs16.69(13.94, 19.75)ng/ml]. Serum Gal-3 concentrations were strongly correlated with eGFR. Other variables with moderate to strong correlations with serum Gal-3 concentration in participants were smoking, diabetes, blood pressure, levels of hemoglobin, albumin, total cholesterol, CysC, P, PTH, NT-proBNP, TnT and 24h proteinuria. Serum Gal-3 were correlated moderately with LVEDD/BSA、PWTd、LVM and LVMI. There was no evidence of higher serum levels of Gal-3 associated with an increased risk of incident coronary artery or abdominal aorta or cardiac valve calcification. Clonclusion: Serum Gal-3 concentrations were significantly highly in CKD early stage. Higher serum levels of Gal-3 were associated with several cardiovascular risk factors and left ventricular geometry remodeling in CKD patients. Serum Gal-3 can serve as potential candidates for prediction risk of cardiovascular events in CKD patients.

Key words: Chronic kidney disease, Galectin-3, Cardiovascular events, Risk