关键词: 胖相关性肾病, 预后, 危险因素

Abstract:

Ｏｂｊｅｃｔｉｖｅ：To study the prognostic characteristic and related risk factors of patients with obesityrelated glomerulopathy (ORG) in China.
Ｍｅｔｈｏｄｏｌｏｇｙ：Two hundred twenty seven patients with ORG were enrolled in this retrospective study,who were diagnosed by renal biopsy in the Research Institute of Nephrology,Nanjing University School of Medicine from January 2003 to December 2015. We observed the clinical,pathological and prognostic materials of ORG patients and searched related risk factors of  prognosis by Cox regression analysis.
Ｒｅｓｕｌｔｓ：The median of followup in this study was 61 months,the median of ΔBMI was 12 kg/m2.At the last observation,37 patients (163%) suffered diabetes,14 patients (62%) reached endstage renal disease,18 patients (79%) had the end point.The 5 year and 10 year cumulative renal survival rates,calculated by KaplanMeier survival analysis,were 936%, and 899%.Multivariate Cox regression analysis showed that severe renal interstitial fibrosis (HR=9102,P=0045), impaired function of the kidney (HR=6140,P=0001) and timeaverage proteinuria (HR=1578,P=0000) were the independent risk factors.
Ｃｏｎｃｌｕｓｉｏｎ：The 5 year and 10 year cumulative renal survival rates of ORG patients were 936%, and 899%.Severe renal interstitial fibrosis, impaired function of the kidney and timeaverage proteinuria were the independent risk factors for renal function progression in ORG patients.

Key words: obesity-related glomerulopathy, prognosis, survival