ISSN 1006-298X      CN 32-1425/R

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肾脏病与透析肾移植杂志 ›› 2021, Vol. 30 ›› Issue (1): 49-53.DOI: 10.3969/j.issn.1006298X.2021.01.009

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多次肾移植患者的预后及影响因素

  

  • 出版日期:2021-02-28 发布日期:2021-02-27

Clinical characteristics in patients with kidney retransplantation

  • Online:2021-02-28 Published:2021-02-27

摘要: 目的:探讨多次肾移植患者的疗效及预后。
方法:回顾性分析空军军医大学西京医院2005年1月至2020年1月行多次肾移植患者32例的临床资料。
结果:32例患者有29例行二次肾移植,其中1例发生超急性排斥反应,切除移植肾脏,1例发生原发性移植肾无功能,11例致敏患者,其中3例高致敏患者再次肾移植时行联合脾窝异位辅助肝移植术,2例术后恢复良好,1例移植肾失功,二次肾移植患者26例预后良好。共有3例三次肾移植患者(既往移植手术均在外院),预后均良好,其中1例为高致敏患者,三次肾移植为亲属活体肾移植,人类白细胞抗原(HLA)0错配。
结论:再次肾移植仍是移植肾失功患者的主要治疗方案,在综合评估病情并制定合理的治疗方案的前提下,可以得到良好的预后。


关键词: 多次肾移植, 疗效, 预后

Abstract: Objective:To investigate the effect and prognosis of multiple renal transplantation patients.
Methodology:Clinical data of 32 cases of renal retransplantation in Xijing Hospital of FMMU from January 2005 to January 2020 were retrospectively analyzed.
Results:Among the 32 patients,29 cases received secondary renal transplantation,including 1 case of hyperacute rejection,1 case of primary renal allograft failure,11 cases of sensitized patients. Among them,3 cases of highly sensitized patients underwent combined splenic fossa auxiliary heterotopic liver transplantation,2 cases recovered well,1 case of graft dysfunction,26 cases of secondary kidney transplantation had good prognosis. The prognosis was good in 3 patients who received the third time  renal transplantation. One of them was highly sensitized and the other was living related kidney transplantation with HLA 0 mismatch. 
Conclusion:Retransplantation is still the main treatment for patients with renal allograft dysfunction,and a good prognosis can be obtained under the premise of comprehensive evaluation of the disease condition and formulation of reasonable treatment plan.


Key words: kidney retransplantation, efficacy, prognosis