关键词: 慢性肾脏病, 代谢综合征, 蛋白尿

Abstract:

Ｏｂｊｅｃｔｉｖｅ：To investigate the prevalence,clinical features of metabolic syndrome（MS）in patients with chronic kidney disease（CKD），and the impact of MS on proteinuria.
Ｍｅｔｈｏｄｏｌｏｇｙ：The subjects of this study were the individuals who were hospitalized in the National Clinical Research Center of Kidney Disease over the period of January to September 2017.Comparatively analyzed the incidence of MS，and the clinical data of patient with MS or without MS.Potential risk factors associated with the developing proteinuria were analyzed using multiple logistic regression.
Ｒｅｓｕｌｔｓ：The incidence of MS in 938 CKD patients was 385%.Serum creatinine(SCr),BUN and proteinuria in patients with MS were significantly higher than those without MS，while the eGFR were lower（P<005)According to the level of proteinuria,patients were divided into different groups.The proportion of MS (484%) in the massive proteinuria（≥35 g/d） group was significantly higher than <04 g/d group (213%) and (04~35)g/d group (371%).Adjusted multivariate logistic regression analysis indicated that elevated fast blood glucose(FBG)， TG/HDLC and WaisttoHip ratio（WHR） were dependent risk factors of massive proteinuria.As the number of MS components increased,the incidence of massive proteinuria was 128%,221%,307%,384%,371% and 333%,respectively.
Ｃｏｎｃｌｕｓｉｏｎ：
The prevalence of MS in patients with CKD was 385%.MS and its components were associated with the presence of proteinuria in CKD patients，and the most significant correlation were the elevated FBG，TG/HDLC ratio and WHR

Key words: chronic kidney disease, metabolic syndrome, proteinuria