ISSN 1006-298X      CN 32-1425/R

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肾脏病与透析肾移植杂志 ›› 2025, Vol. 34 ›› Issue (2): 168-173.DOI: 10.3969/j.issn.1006-298X.2025.02.014

• 肾脏病临床 • 上一篇    下一篇

细胞外囊泡在慢性肾脏病心血管疾病中的作用

  

  • 出版日期:2025-04-28 发布日期:2025-05-07

Extracellular vesicles in cardiovascular disease in patients with chronic kidney disease

  • Online:2025-04-28 Published:2025-05-07

摘要: 慢性肾脏疾病(CKD)可通过多种机制造成内皮功能障碍、血管钙化、细胞外囊泡(EV)释放增加等,促进心血管疾病(CVD)的发生、发展。EV在CVD中起着多方面的作用,可作为诊断和预后判断的生物标志物、治疗手段和药物递送载体。本文就EV在CKD患者CVD发展中的作用机制、应用现状及前景作一综述。


关键词: 慢性肾脏病, 细胞外囊泡, 心血管疾病, 生物标志, 物药物递送治疗

Abstract: In chronic kidney disease (CKD) can lead to endothelial dysfunction,vascular calcification and increased release of extracellular vesicles (EV) which promote the development of cardiovascular disease (CVD). EV plays an important role in this process and serves as diagnostic biomarkers, therapeutic approach and drug delivery carriers. This article reviewed the mechanism, application and prospect of EV in the development of CVD in patients with CKD.


Key words: chronic kidney disease, extracellular vesicles, cardiovascular disease, biomarker, diverse therapeutic application