关键词: 急性肾损伤, 慢性肾脏病, 铁死亡, 炎症, 纤维化

Abstract: Acute kidney injury (AKI) is an acute and critical illness with high morbidity and mortality. In recent years, a growing body of studies have shown that renal maladaptation following AKI results in chronic kidney disease (CKD). Ferroptosis, a novel form of non-apoptotic cell death characterized by iron overload and lipid peroxidation, is believed to play a significant role in the progression of AKI to CKD. This article provides a review of the classical regulatory mechanisms of ferroptosis and its potential involvement in the pathological mechanisms in the progression of AKI to CKD.

Key words: acute kidney injury, chronic kidney disease, ferroptosis, inflammation, fibrosis