IgG抗体Fc片段受体ⅡBI232T基因多态性与自身免疫性疾病

doi:10.3969/j.issn.1006-298X.2019.03.013

肾脏病与透析肾移植杂志 ›› 2019, Vol. 28 ›› Issue (3): 257-261.DOI: 10.3969/j.issn.1006-298X.2019.03.013

IgG抗体Fc片段受体ⅡBI232T基因多态性与自身免疫性疾病

出版日期:2019-06-28 发布日期:2019-07-23

Fc fragment of IgG receptor Ⅱbisoleucine 232 threonine and autoimmune disease

Online:2019-06-28 Published:2019-07-23

摘要/Abstract

摘要：

IgG抗体Fc片段受体ⅡB(FcγRⅡB)在免疫调节中起重要作用，FcγRⅡB功能异常可导致多种自身免疫性疾病和免疫功能紊乱。近年来一些研究已经证实FcγRⅡBI232T与自身免疫性疾病的发生、发展有一定的关联。本文总结FcγRⅡBI232T基因多态性与自身免疫疾病易感性、临床表现及治疗反应的最新进展。

关键词: IgG抗体Fc片段受体, 单核苷酸基因多态性, 自身免疫性疾病

Abstract:

FcγRs are members of the immunoglobulin superfamily of proteins and are found on many haematopoietic lineages. FcγRⅡB is a singlechain molecule that contains an immunereceptor tyrosinebased inhibitory motif (ITIM) in its cytoplasmic domain. FcγRⅡB dysfunction can result in systemic autoimmune diseases,such as systemic lupus erythematosus,Kawasaki disease and Ankylosing Spondylitis. This review is focus on recent studies on the correlation of FcγRⅡBI232T polymorphisms with susceptibility,activity and treatment response of autoimmune disease.

Key words: Fc fragment of IgG receptor, single nucleotide polymorphism, autoimmune disease

翟修文，陈朝红，刘志红. IgG抗体Fc片段受体ⅡBI232T基因多态性与自身免疫性疾病[J]. 肾脏病与透析肾移植杂志, 2019, 28(3): 257-261.

ZHAI Xiuwen,CHEN Zhaohong,LIU Zhihong. Fc fragment of IgG receptor Ⅱbisoleucine 232 threonine and autoimmune disease[J]. Chinese Journal of Nephrology, Dialysis & Transplantation, 2019, 28(3): 257-261.

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ISSN 1006-298X CN 32-1425/R

IgG抗体Fc片段受体ⅡBI232T基因多态性与自身免疫性疾病

Fc fragment of IgG receptor Ⅱbisoleucine 232 threonine and autoimmune disease

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