ISSN 1006-298X      CN 32-1425/R

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肾脏病与透析肾移植杂志 ›› 2019, Vol. 28 ›› Issue (3): 262-266.DOI: 10.3969/j.issn.1006-298X.2019.03.014

• 论文 • 上一篇    下一篇

流式细胞术在系统性轻链型淀粉样变性诊断中的应用

  

  • 出版日期:2019-06-28 发布日期:2019-07-23

Application of flow cytometry  technigue in diagnosis of  systemic light chain amyloidosis

  • Online:2019-06-28 Published:2019-07-23

摘要:

系统性轻链型淀粉样变性(AL)是由单克隆浆细胞分泌异常折叠的免疫球蛋白在组织沉积导致的多器官功能损害性疾病。目前,流式细胞术已广泛应用于血液系统肿瘤的疾病监测。根据浆细胞表面表达的抗原,可区分正常和异常的浆细胞,检测异常浆细胞免疫表型,判断肿瘤负荷。近年来研究表明,流式细胞术在AL的疾病诊断、鉴别和预后评估中具有潜在的临床价值,为疾病治疗提供新靶点。

 

关键词: 系统性轻链型淀粉样变性, 流式细胞术, 浆细胞免疫表型

Abstract:

Systemic light chain amyloidosis (AL) is a kind of disease caused by misfolded protein secreted by monoclonal plasma cells.At present,flow cytometry (FCM) has been widely used in a variety of diseases,including hematologic tumors.By detecting the number and the expression of antigen of the cells,FCM is sensitive in determining tumor load,as well as distinguishing normal and monoclonal plasma cells. In this review,we will discuss the application of plasma cell immunophenotype analysis in AL and explore its significance in diagnosis and prognosis,in order to seek the novel therapeutic target.

Key words: systemic light chain amyloidosis, flow cytometry, plasma cell immunophenotype