关键词: 糖尿病, 器官移植, 危险因素, 治疗

Abstract:

With the development of surgical technique and immunosuppressants,the success rate of organ transplantation has been increasing.Meanwhile,the number of transplant recipents suffered from metabolic diseases is growing fast.Posttransplant diabetes mellitus (PTDM) is a common complication after solid organ transplantation and is associated with risks of graft loss,cardiovascular morbidity and mortality.Risk factors for PTDM include older age,genetic background,obesity,hepatitis C virus infection and use of immunosuppressant agents (corticosteroids,calcineurin inhibitors,and mammalian target of rapamycin inhibitor).Management of PTDM should be started before the transplantation plan to properly screen high risk patients.Even though PTDM management is similar to that of general type 2 diabetes,therapeutic approaches must be made with consideration of drug interactions between immunosuppressive agents,glucoselowering medications,and graft rejection and function.

Key words: diabetes mellitus, organ transplantation, risk factors, management