关键词: 成体肾干/祖细胞, 分化型小管细胞, 包囊, 足细胞, 肾脏再生

Abstract:

Many studies support the presence of adult kidney stemprogenitor cells, this area has become a new research direction in kidney damage. Many research provide proofs for adult kidney stemprogenitor cells protecting from kidney damage, but the academic circles still argue the existence of adult kidney stemprogenitor cells which promote kidney development and regeneration. A subset of CD133 and CD24 positive progenitor cells exists in adult kidney tubules and Bowmans capsule, as the labeled molecules of adult kidney stemprogenitor cells, which provide a real possibility for injured renal tubular cell regeneration. Autologous stemprogenitor cells cultivate in vitro provide a fundamental and promising treatment potentially for patients with chronic kidney disease, especially with ESRD.

Key words: adult kidney stem-progenitor cells, differentiated tubule cells, Bowman‘s capsule, podocyteskidney regeneration