关键词: 腹膜透析, 心血管钙化, 演变, 预后

Abstract:

Ｏｂｊｅｃｔｉｖｅ：To dynamically observe the morbidity and evolution of cardiovascular calcification in peritoneal dialysis (PD) patients, and to analyze the factors influencing calcification and its clinical significance.
Ｍｅｔｈｏｄｏｌｏｇｙ：One hundred fifty PD patients were enrolled in a prospectively study. Their baseline clinical features and the morbidity of cardiovascular calcification were assessed. The durations of followup were 30 months. The calcification was assessed at 0, 12 and 24 months, respectively. The Logistic regression was used to analysis factors affecting cardiovascular calcification and progression. The KaplanMeier method was used to calculate the allcause mortality, cardiovascular disease (CVD) mortality and nonfatal cardiovascular events (CVE), and COX regression analysis was associated with the risk factors.
Ｒｅｓｕｌｔｓ：573% of patients had calcification at baseline, and at the end of followup, the cardiovascular calcification rate increased to 632%, and calcification progression was observed in 535% of patients. 53% of patients died during followup, the most common cause of death was CVD (75%), and the incidence of CVE was 193%. The all-cause mortality (P=0004) and CVD mortality (P=0002) were significantly higher in patients with clinically significant calcification than in other patients. Hypoalbuminemia and mitral calcification are independent risk factors for allcause mortality and CVD mortality. Age more than 46 years, lowdensity lipoprotein cholesterol and coronary artery calcification + heart valve calcification were independent risk factors for CVE.
Ｃｏｎｃｌｕｓｉｏｎ：
PD patients with high morbidity of cardiovascular calcification and the progression of calcification was rapid. Cardiovascular calcification may be closely related to the occurrence of CVD events, and it could be negative effects on prognosis. 

Key words: peritoneal dialysis, cardiovascular calcification, evolution, prognosis