ISSN 1006-298X      CN 32-1425/R

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肾脏病与透析肾移植杂志 ›› 2015, Vol. 24 ›› Issue (5): 459-462.

• 论文 • 上一篇    下一篇

半乳糖凝集素3与慢性肾脏病风险评估

  

  • 出版日期:2015-10-28 发布日期:2015-10-30

 Galectin-3 and Chronic Kidney Disease

  • Online:2015-10-28 Published:2015-10-30

摘要:

摘 要 慢性肾脏病(CKD)是世界性的公共卫生问题。我国CKD发生率连年递增。除进展至终末期肾病(ESRD)外,CKD并发心血管疾病的风险显著升高。CKD疾病的本质是肾脏慢性炎症和器官纤维化,涉及众多代谢产物和信号通路。半乳糖凝集素3(Gal-3)是体内一种重要的多功能蛋白质,具有广泛的病理生理意义。新近的多项研究发现Gal-3与心肾疾病的发生和进展关系紧密。本文综述Gal-3在CKD心脏、肾脏事件风险评估中的认识进展。

关键词: 慢性肾脏病, 心血管疾病, 半乳糖凝集素-3

Abstract:

 ABSTRACT China has a high prevalence of chronic kidney disease (CKD). CKD imposes an enormous burden on public health resources for the reasons of development of end-stage renal disease (ESRD) and complications of cardiovascular diseases. Galectin-3 is a member of the multifunctional proteins comprising soluble β-galactoside-binding lectins that have regulatory roles in fibrogenesis, inflammation, tissue repair and cell proliferation. This review will focus on the relevant research progresses of Galectin-3 in CKD. 

Key words: chronic kidney disease, cardiovascular, disease Galectin-3