ISSN 1006-298X      CN 32-1425/R

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肾脏病与透析肾移植杂志 ›› 2014, Vol. 23 ›› Issue (1): 68-72.

• 论文 • 上一篇    下一篇

特发性膜性肾病组织形态学改变与预后的关系

  

  • 出版日期:2014-02-28 发布日期:2014-02-25

Association of renal pathological features and the prognosis in patients with membranous nephropathy

  • Online:2014-02-28 Published:2014-02-25

摘要:

摘要  特发性膜性肾病病程迁延、病情易反复,预后差别较大,部分患者可自行或治疗后缓解,持续肾病状态者则最终进展至ESRD.目前治疗以免疫抑制为主,具有一定的疗效,但如过度治疗亦给患者带来潜在的风险。预后因素分析研究有助于给出合理的治疗方案,避免过量免疫抑制治疗相关的不良反应。男性、老年、持续大量蛋白尿、血肌酐升高是其预后不良的临床指标,然而肾活检组织形态学改变对其预后影响及能否用于指导治疗目前尚无定论。本文就这方面的研究做一综述。

关键词: 膜性肾病, 肾脏病理, 预后

Abstract:

ABSTRACT The course of idiopathic membranous nephropathy is variable. Accurate prediction of renal outcome would allow optimal treatment decisions. The identification of parameters that predict prognosis with sufficient accuracy would allow individualized treatment and avoid unnecessary immunosuppressive therapy. Well-known risk factors for prognosis such as male, old age, persistent nephrotic proteinuria, increasing serum creatine. But the effects of morphological parameters on prognosis are conflicting.

Key words:  membranous nephropathy,  renal pathology,  prognosis