关键词: 局灶节段性肾小球硬化,  , 足细胞,  , 可溶性尿激酶型纤溶酶原激活物受体

Abstract:

ABSTRACT   Focal segmental glomerulosclerosis (FSGS) is a major cause of end-stage renal disease (ESRD). And podocyte plays a key role in the development of  FSGS. Circulating permeability factor has been considered to be pathogenic for FSGS. Recently,  it had found that, by binding to β3 integrin on podocytes, suPAR (soluble urokinase-type plasminogen activator receptor) induced podocyte foot process effacement, proteinuria and initiation of FSGS. Furthermore, high concentration of serum suPAR had been confirmed in approximately two-thirds of patients with FSGS. Here, we will review the role and specificity of suPAR in primary FSGS, and the role of suPAR in clinical practice of FSGS.

Key words: Focal segmental glomerulosclerosis,   , podocyte ,   , soluble urokinase-type plasminogen activator receptor