Ⅲ型高脂蛋白血症肾脏损害的临床病理特征——附3例报告并文献复习

doi:10.3969/j.issn.1006-298X.2019.05.004

肾脏病与透析肾移植杂志

Ⅲ型高脂蛋白血症肾脏损害的临床病理特征——附3例报告并文献复习

出版日期:2019-10-28 发布日期:2020-01-07

Renal disease associated with type Ⅲ hyperlipoproteinemia:a report of three cases with literature review

Online:2019-10-28 Published:2020-01-07

摘要/Abstract

摘要： 目的：探讨Ⅲ型高脂蛋白血症合并肾损害患者的临床病理特征。
方法：回顾分析3例（2例女性，1例男性）Ⅲ型高脂蛋白血症合并肾损害患者的临床、实验室指标及病理特点。
结果：3例患者均表现为蛋白尿，无镜下血尿，血脂及载脂蛋白E（ApoE）升高，肾小球内可见CD68染色阳性的泡沫细胞，电镜下泡沫细胞胞质内见脂性空泡和（或）致密层状的嗜锇性小体分布。
结论：Ⅲ型高脂蛋白血症可引起肾脏损害，病理表现为肾小球系膜区和袢内泡沫细胞聚集。

关键词: Ⅲ型高脂蛋白血症, 载脂蛋白E, 泡沫细胞

Abstract: Ｏｂｊｅｃｔｉｖｅ：To explore clinicopathological features of 3 patients with type Ⅲ hyperlipoproteinemia and renal diseases.
Ｍｅｔｈｏｄｏｌｏｇｙ：Three patients with type Ⅲ hyperlipoproteinemia and renal biopsyproven kidney diseases were retrospectively evaluated. The clinical manifestation and pathological features were analyzed.
Ｒｅｓｕｌｔｓ：All three patients (2 females and 1 male) had proteinuria,significantly elevated blood lipids and apolipoprotein E (ApoE),but without microhematuria.Histopathology revealed presence of CD68 positive foam cells in the glomerulus.Electron microscopy showed lipid vacuoles or osmiophilic lamellar bodies in the cytoplasm of foam cells.
Ｃｏｎｃｌｕｓｉｏｎ：
Renal diseases associated with type Ⅲ hyperlipoproteinemia was characterized by proteinuria,hyperlipidemia,and increased glomerular volume with foam cells infiltration.

钟永忠,朱莹,曾彩虹. Ⅲ型高脂蛋白血症肾脏损害的临床病理特征——附3例报告并文献复习[J]. 肾脏病与透析肾移植杂志, DOI: 10.3969/j.issn.1006-298X.2019.05.004.

ZHONG Yongzhong,,ZHU Ying,ZENG Caihong. Renal disease associated with type Ⅲ hyperlipoproteinemia:a report of three cases with literature review[J]. Chinese Journal of Nephrology, Dialysis & Transplantation, DOI: 10.3969/j.issn.1006-298X.2019.05.004.

ISSN 1006-298X CN 32-1425/R

Ⅲ型高脂蛋白血症肾脏损害的临床病理特征——附3例报告并文献复习

Renal disease associated with type Ⅲ hyperlipoproteinemia:a report of three cases with literature review

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