Abstract:

Acute kidney injury can be caused by many factors,and activation of the complement plays an important role in acute kidney injury.In acute kidney injury,complement system can be activated through  classic pathway,mannosebinding lectin pathway and alternative pathway,and alternative pathway is most important.The membrane attack complex together with the downstream molecules of  complement system,such as C3a and C5a will cause the damage of  kidney.Complement regulatory proteins can inhibit the over activation of complement system,and their impaired function will lead to a series of kidney diseases and aggravate the kidney injury.In this review we will describe the role of  complement in acute kidney injury,in order to provide new thoughts of the specific clinical therapy of acute kidney injury.

Key words: acute kidney injury, complement, alternative pathway