血细胞微粒与慢性肾脏病

肾脏病与透析肾移植杂志 ›› 2016, Vol. 25 ›› Issue (2): 170-175.

血细胞微粒与慢性肾脏病

出版日期:2016-04-28 发布日期:2016-05-04

Update on blood cell microparticles in chronic kidney disease

Online:2016-04-28 Published:2016-05-04

摘要/Abstract

摘要：

[摘要]：微粒（MPs）是细胞活化或凋亡时细胞膜出芽释放至血浆中的直径为0.1~1μm的无核微小囊泡状物质。MPs膜外侧表达含阴离子的磷脂酰丝氨酸及特异性母细胞源性蛋白质，同时MPs携带母细胞质的某些成分（DNA和RNA等）。通过MPs膜蛋白质抗体的检测可判断其母细胞来源，进而判断疾病起源。研究表明，慢性肾脏病（CKD）患者血循环中MPs产生显著增加，MPs在CKD发生、发展中发挥重要作用。开展微粒检测等相关研究可能为临床上阐明微粒在CKD发生中的作用、监测病情进展、判断药物疗效及疾病预后提供借鉴和帮助。因此，本文旨在对MPs在CKD中的作用作一综述。

关键词: 血细胞微粒, 慢性肾脏病

Abstract:

[Abstract] Microparticles (MPs) from blood cells are nuclear-free plasma membrane vesicles shed from apoptotic or activated cells, which range in diameter is from 0.1μm to 1μm and carries specific parental proteins and components (DNA and RNA) from maternal cytoplasma. Accordingly, the detection of MP membrane proteins can help to tell the source of parental cells and to detect the origin of diseases. It has been reported that the level of circulating MPs is increased during the progression of chronic kidney disease (CKD). Therefore, improved understanding for the mechanism of governing MPs release and their detection methods may be critical to monitor the progression, drug efficacy, and prognosis of CKD. This review summarizes the current knowledge of the molecular mechanisms involved in MP formation and their diverse roles in CKD.

Key words: blood cell microparticle, chronic kidney disease

鲁荐|马坤岭 . 血细胞微粒与慢性肾脏病[J]. 肾脏病与透析肾移植杂志, 2016, 25(2): 170-175.

Jian Lu|Kun Lingma. Update on blood cell microparticles in chronic kidney disease[J]. Chinese Journal of Nephrology, Dialysis & Transplantation, 2016, 25(2): 170-175.

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