关键词: 尿毒症, 肌少症, 发病机制

Abstract:

Abstract: Sarcopenia is a syndrome characterized by progressive and generalized loss of skeletal muscle mass and strength. Ageing is associated with sarcopenia, and end-stage renal disease accelerates the normal physiological muscle wasting resulting in an increasing prevalence of sarcopenia, which is named uraemic sarcopenia. There are several mechanisms that may be involved in the onset and progression of uraemic sarcopenia, such as hormones, changes in immune and muscle cells, metabolic acidosis, reducing protein intake and so on. Uraemic sarcopenia presents a high probability for morbidity and mortality, and consequently a high priority for muscle wasting prevention and treatment in these patients.

Key words: Uraemic, sarcopenia, pathogenesis