关键词: 诱导性多能干细胞, 肾脏再生, 慢性肾脏病

Abstract:

ABSTRACT Differentiated somatic cells including renal tubular epithelial cells and mesangial cells can be reprogrammed to an embryonic-like state, named induced pluripotent stem cells (iPSC). These reprogrammed cells could differentiate into cell types of the three germ layers in vitro and in teratomas in vivo. Injection of iPSC or podocyte derived from iPSC could alleviate renal injury in kidney disease models. In this paper, the researching progressions of induced pluripotent stem cells in renal regeneration will be reviewed.

Key words: induced pluripotent stem cells, renal regeneration, chronic kidney disease