关键词: 肾癌, 肾切除术, 残余肾功能, 慢性肾脏病

Abstract:

With the advancements in diagnostic technology and longer life expectancies,the incidence of renal carcinoma is increasing.Surgical resection remains the goldstandard treatment for renal cancer,including radical nephrectomy and partial nephrectomy,while the risk of newonset or accelerated chronic kidney disease(CKD) after nephrectomy increased.As CKD is an independent risk factor for cardiovascular disease and death,residual renal function(RRF)after nephrectomy got valued.Studies shown that radical nephrectomy increased the risk of adverse renal outcome,as well as the baseline renal function,proteinuria,intrinsic abnormalities in nonneoplastic renal parenchyma,tumor stage,demographics,comorbid conditions (such as diabetes mellitus,hypertension),warm ischemia and other factors.Therefore,it needs further understanding and improvement to better evaluate and preserve the RRF postnephrectomy when achieve oncological outcomes.

Key words: renal cancer, nephrectomy, residual renal function, chronic kidney disease