ISSN 1006-298X      CN 32-1425/R

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肾脏病与透析肾移植杂志 ›› 2018, Vol. 27 ›› Issue (2): 147-150.DOI: 10.3969/j.issn.1006-298X.2018.02.009

• 论文 • 上一篇    下一篇

卡维地洛对糖尿病肾病血液透析患者心功能的影响

  

  • 出版日期:2018-04-28 发布日期:2018-05-02

Effect of carvedilol on cardiac function of hemodialysis patients with diabetic nephropathy

  • Online:2018-04-28 Published:2018-05-02

摘要:

目的:探讨卡维地洛对糖尿病肾病的维持血液透析患者左心功能的影响。
方法:回顾性分析2009年10月至2013年6月期广东省人民医院肾内科糖尿病肾病血液透析患者,根据是否给予卡维地洛将患者分为两组,用心脏彩色超声评估治疗1年后心功能变化,并观察两组生存率。
结果:入选72例患者,其中卡维地洛组14例,对照组58例。治疗前后,卡维地洛组的左室射血分数改善,而对照组无改善。但两组生存率无统计学差异。
结论:卡维地洛能改善糖尿病肾病血液透析患者的左室射血分数。

关键词: 糖尿病肾病, 维持性血液透析, 卡维地洛, 左室射血分数

Abstract:

Objective:To evaluate the effect of carvedilol on cardiac function of hemodialysis patients with diabetic nephropathy.
Methodology:Seventytwo patients were collected in Guangdong General Hospital hemodialysis center from October 2009 to June 2013 in this retrospective study. They were divided into carvedilol therapy group (n=14) and control group (n=58). Echocardiography measurement was performed before and one year after treatment. Survival rate was compared between two groups.
Results:In the therapy group, the mean left ventricular ejection fraction (LVEF) after oneyear followup was elevated than that before treatment (P=0047 6). However, no similar improvement of LVEF was observed in the control group, but there was no significant difference of survival rates between two groups.
Conclusion:Carvedilol can improve the LVEF of hemodialysis patients with diabetic nephropathy.

Key words: diabetic nephropathy, maintenance hemodialysis, carvedilol, left ventricular ejection fraction