关键词: 肾单位, 足细胞, 祖细胞, 再生

Abstract:

Although mammalian postnatal kidney cant generate new nephrons, suggesting a low level of regenerative competence, both tubular epithelial cells and podocytes show the characteristics of proliferation and regeneration post acute kidney injury(AKI). There have been two opinions of the regeneration. On one hand, it is persistent local progenitor that proliferates, differentiates and generates epithelium post injury; on the other hand, remaining mature local epithelial cell may take the main role to repair, by reentering miotosis and replacing the injured cell. Whether the repair involves a persistent progenitor population or any mature epithelial cell remains argumentative, thus we review references here, in order to elaborate the mechanism of progenitor regeneration and differentiation redifferentiation of epithelial cell, and summarize the research progress of this field.

Key words: nephron, podocyte, progenitor, regeneration