关键词: 毛细血管渗漏综合征, 毛细血管渗透性, 细胞因子, 急性肾损伤

Abstract:

Capillary leak syndrome（CLS）is a serious complication of systemic inflammatory response syndrome,because of the cell injury of capillary endothelial,increased vascular permeability with a large number of plasma proteins leaking into the tissues.The clinical manifestations of CLS include progressive systemic edema,chest and abdominal cavity effusion,oliguria,hypotension,hypoxemia,hypoproteinemia,and  multiple organ failure in serious condition.Acute kidney injury is commonly seen in CLS.Fluid management is a critical part of the treatment of CLSHigh molecular weight starches are theoretically attractive resuscitative fluids in those with capillary leak.Patients with CLS are at high risk of noncardiogenic pulmonary edema during fluid resuscitation.Steroids are effective in several causes of CLS.An effective abortive treatment in CLS appears to be highdose intravenous immunoglobulins.

Key words: capillary leak syndrome, capillary permeability, cytokines, acute kidney injury