ISSN 1006-298X      CN 32-1425/R

导航

肾脏病与透析肾移植杂志 ›› 2021, Vol. 30 ›› Issue (2): 189-193.DOI: 10.3969/j.issn.1006298X.2021.02.019

• • 上一篇    下一篇

移植肾移入性糖尿病肾病

  

  • 出版日期:2021-04-28 发布日期:2021-06-06

Renal transplant recipient from a donor with diabetic nephropathy#br#

  • Online:2021-04-28 Published:2021-06-06

摘要: 患者青年女性,心脏死亡器官捐献供肾右侧肾移植术后4年余,肾功能长期稳定,少量尿蛋白逐渐降至正常,血糖持续正常,近3月随群体反应性抗体Ⅱ类抗体阳性出现血清肌酐轻度升高。供体明确糖尿病病史15年,供肾肾脏病理表现为糖尿病肾病(DN);患者肾移植术后半年常规肾活检表现为供肾移入性DN;术后4年肾活检DN病理改变发生部分逆转,合并移植肾小球病。经治疗,直至术后随访6年,患者肾功能稳定。


关键词: 肾移植, 零点活检, 糖尿病肾病 

Abstract: A 24yearold female as a nondiabetic recipient received renal allograft from a donation after cardiac death (DCD) donor with diabetes of 15 years.After transplantation,mild proteinuria gradual decreased to a normal range after 6 months and the kidney functioned well with standard immunosuppression. Timezero renal biopsy showed evidence of diabetic nephropathy (DN). Sequential protocol biopsies demonstrated gradual resolution of the preexisting DN from 6 months to 4 years after transplantation,with appearance of transplant glomerulopathy. The renal function remained stable at the 6year followup.


Key words: kidney transplantation, time-zero renal biopsy, diabetic nephropathy