ISSN 1006-298X      CN 32-1425/R

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肾脏病与透析肾移植杂志 ›› 2021, Vol. 30 ›› Issue (2): 165-169.DOI: 10.3969/j.issn.1006298X.2021.02.014

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核因子E2相关因子2信号通路与肾脏疾病

  

  • 出版日期:2021-04-28 发布日期:2021-06-06

Role of nuclear factor erythroid 2related factor 2 in kidney disease

  • Online:2021-04-28 Published:2021-06-06

摘要: 核因子E2相关因子(Nrf2)是调控抗氧化、抗炎类基因的关键转录因子。Nrf2激动剂具有显著肾脏保护作用,是创新药物重要靶点。本文将介绍Nrf2信号通路和肾脏疾病的研究进展以及Nrf2激动剂的临床应用。


关键词: 核因子E2相关因子2, 氧化应激, 糖尿病肾病, 急性肾损伤, 狼疮性肾炎

Abstract: Nuclear factor erythroid 2 related factor 2 (Nrf2) is a transcription factor that regulates the expression of a vast array of cytoprotective genes including antioxidant and antiinflammatory genes.Strategy aimed at restoring Nrf2 activity could potentially retard chronic kidney disease progression.This review focuses on the research progress of the Nrf2 signaling pathway,its role in renal diseases,and the clinical application of Nrf2 agonists.


Key words: nuclear factor erythroid 2 related factor 2, oxidative stress, diabetic nephropathy, acute kidney injurylupus nephritis