关键词: 肝细胞癌, 仑伐替尼, 肾病综合征, 局灶节段性肾小球硬化, 血栓性微血管病

Abstract:  This article reports one case of secondary nephrotic syndrome (NS) caused by Lenvatinib in the treatment of advanced primary hepatocellular carcinoma. The patient was a 65⁃year⁃old male who was admitted to the hospital with chief complaints of abdominal distension and edema for 20 days, 1 month after hepatocellular carcinoma surgery. During the treatment for hepatocellular carcinoma with Lenvatinib, he developed NS accompanied by hypertension. Renal biopsy revealed focal segmental glomerulosclerosis (FSGS) accompanied by thrombotic microangiopathy (TMA). After discontinuing Lenvatinib and administering angiotensin receptor blocker therapy, NS in this patient gradually reached partial remission. During 6 months of outpatient follow⁃up, no recurrence of NS was observed in this patient.