肾脏病与透析肾移植杂志 ›› 2023, Vol. 32 ›› Issue (1): 90-94.DOI: 10.3969/j.issn.1006-298X.2023.01.019
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摘要： 青年男性患者,肾移植术后7年,应用吗替麦考酚酯、他克莫司、泼尼松等免疫抑制治疗,临床表现为大量蛋白尿伴少量镜下血尿,肾活检组织学为局灶节段性肾小球硬化,免疫荧光肾小球IgA沉积,同时小动脉壁中膜和外膜见滴状透明变性。结合临床,考虑移植肾IgA肾病合并钙调磷酸酶抑制剂肾毒性。
关键词: 肾移植, IgA肾病, 局灶节段性肾小球硬化, 钙调磷酸酶抑制剂肾毒性
Abstract: A 34-year-old male presented with massive proteinuria and mild microscopic hematuria seven years after kidney transplantation,treated with immunosuppressive therapy of mycophenolate mofetil, tacrolimus and prednisone. Renal biopsy revealed focal segmental glomerulosclerosis with IgA deposition, and nodular hyaline deposits in the media and adventitia of arterioles.The final diagnosis was allograft IgA nephropathy with calcineurin inhibitor nephrotoxicity.
Key words: renal transplantation, IgA nephropathy, focal segmental glomerulosclerosis, calcineurin inhibitor nephrotoxicity
徐峰, 曾彩虹. 移植肾IgA肾病合并慢性钙调蛋白抑制剂肾毒性[J]. 肾脏病与透析肾移植杂志, 2023, 32(1): 90-94.
XU Feng, ZENG Caihong. IgA nephropathy with chronic calcineurin inhibitor nephrotoxicity after kidney transplantation[J]. Chinese Journal of Nephrology, Dialysis & Transplantation, 2023, 32(1): 90-94.
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http://www.njcndt.com/CN/Y2023/V32/I1/90
