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肾脏病与透析肾移植杂志 ›› 2025, Vol. 34 ›› Issue (6): 595-595.DOI: 10.3969/j.issn.1006⁃298X.2025.06.018

• 临床集锦 • 上一篇    

英夫利西单抗治疗克罗恩病并发急性间质性肾炎

  

  • 出版日期:2025-12-28 发布日期:2025-12-29

Crohn’s disease complicated with acute interstitial nephritis during infliximab maintenance treatment

  • Online:2025-12-28 Published:2025-12-29

摘要: 14 岁女性患者,确诊克罗恩病 1 年余,美沙拉嗪等药物治疗效果不佳,改为英夫利西单抗注射治疗。治疗 6 个周期后,患者出现血清肌酐升高。此后因发热咳嗽行抗感染治疗,血清肌酐进一步升高。肾活检提示急性间质性肾炎(AIN)。本文就克罗恩病合并 AIN 的原因展开讨论,探讨药物和其余可疑致病因素对 AIN 产生的影响。

关键词: font-family:Inter, -apple-system, BlinkMacSystemFont, ", font-size:16px, background-color:#FFFFFF, ">急性间质性肾炎、英夫利西单抗、克罗恩病

Abstract: A 14⁃year⁃old female is administered infliximab monoclonal antibody injection due to poor response to mesalazine, after she was diagnosed with Crohn’s disease (CD) one year ago. Serum creatinine rose after six cycles, which further elevated when she received anti⁃infective therapy for fever and cough. Renal biopsy revealed acute interstitial nephritis (AIN). This article discussed the etiology of CD complicated with AIN, exploring the possible effects of drugs and other suspected etiological factors on AIN.

Key words: font-family:Inter, -apple-system, BlinkMacSystemFont, ", font-size:16px, background-color:#FFFFFF, ">acute interstitial nephritis、infliximab、Crohn’s disease