CD4+T细胞Th1/Th2及Th17/Treg平衡状态在IgA肾病间质纤维化中的意义

doi:10.3969/j.issn.1006-298X.2024.05.003

肾脏病与透析肾移植杂志 ›› 2024, Vol. 33 ›› Issue (5): 417-423.DOI: 10.3969/j.issn.1006-298X.2024.05.003

CD4+T细胞Th1/Th2及Th17/Treg平衡状态在IgA肾病间质纤维化中的意义

出版日期:2024-10-28 发布日期:2024-11-01

Th1/Th2 and Th17/Treg balance status of CD4+T cells in interstitial fibrosis of IgA nephropathy

Online:2024-10-28 Published:2024-11-01

摘要/Abstract

摘要： 目的：探讨CD4+T细胞亚群Th1、Th2、Th17、Treg及Th1/Th2、Th17/Treg比值与IgA肾病(IgAN)间质纤维化的关系。
方法：收集2022年6月至2023年12月在济南威高肾科医院经肾活检确诊的86例IgAN患者,按照肾间质纤维化程度分为T0 组(n=36)、T1 组(n=28)和T2 组(n=22)。选取同期的健康体检者43例为对照组。采用流式细胞术检测外周血中CD4+T细胞亚群的比例,酶联免疫吸附试验检测外周血中CD4+T淋巴细胞因子:γ干扰素(IFN-γ)、白细胞介素(IL)-4、IL-17和转化生长因子β(TGF-β)。
结果：随着肾间质纤维化程度的增加,Th1、Treg及Th1/Th2逐渐降低,而Th2、Th17及Th17/Treg逐渐升高(P<0.05)。IL-4、IL-17和TGF-β水平随着IgAN肾间质纤维化程度的增加而升高(P<0.05),而IFN-γ水平在各组间的差异无统计学意义。Pearson相关性分析显示,Th1/Th2、Th17/Treg与IgAN患者的临床指标呈弱相关性(P<0.05)。
结论：IgAN患者外周血中CD4+T细胞亚群Th1/Th2、Th17/Treg比值失衡,可能参与了肾间质纤维化的发生发展。

关键词: IgA肾病, 肾间质纤维化, CD4+T细胞, Th1/Th2Th17/Treg

Abstract: Ｏｂｊｅｃｔｉｖｅ：The imbalance of differentiation of CD4+T cells and the imbalance of Th1/Th2 and Th17/Treg are closely related to the occurrence of IgA nephropathy (IgAN).
Ｍｅｔｈｏｄｏｌｏｇｙ：Total of 86 IgAN patients diagnosed by histological biopsy (divided into T0 group (n=36), T1 group (n=28) and T2 group (n=22) according to the degree of renal interstitial fibrosis) and 43 healthy subjects in Jinan Weigao Nephrology Hospital from June 2022 to December 2023 were collected, and the proportion of CD4+T cell subsets in peripheral blood and the cytokines interferon γ (IFN-γ), interleukin(IL)-4, IL-17 and transforming growth factor-β (TGF-β) in peripheral blood were detected to explore the correlation between Th1/Th2, Th17/Treg balance and renal interstitial fibrosis of IgAN.
Ｒｅｓｕｌｔｓ：Showed that with the increase of renal interstitial fibrosis degree, Th1, Treg and Th1/Th2 gradually decreased, while Th2, Th17 and Th17/Treg gradually increased. And the levels of cytokines IL-4, IL-17 and TGF-β were increased with the increase of IgAN renal interstitial fibrosis degree. Meanwhile, there was a weak correlation between Th1/Th2、Th17/Treg and the clinical data of IgAN patients.
Ｃｏｎｃｌｕｓｉｏｎ：The Th1/Th2, Th17/Treg ratio of CD4+T cell subsets in peripheral blood of IgAN patients is unbalanced, which may be involved in the occurrence and development of renal interstitial fibrosis.

Key words: IgA nephropathy, renal interstitial fibrosis, CD4+T cells, Th1/Th2, Th17/Treg

齐惠, 刘月, 岳冀, 孟建中. CD4+T细胞Th1/Th2及Th17/Treg平衡状态在IgA肾病间质纤维化中的意义[J]. 肾脏病与透析肾移植杂志, 2024, 33(5): 417-423.

QI Hui, LIU Yue, YUE Ji, MENG Jianzhong. Th1/Th2 and Th17/Treg balance status of CD4+T cells in interstitial fibrosis of IgA nephropathy[J]. Chinese Journal of Nephrology, Dialysis & Transplantation, 2024, 33(5): 417-423.

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ISSN 1006-298X CN 32-1425/R

CD4+T细胞Th1/Th2及Th17/Treg平衡状态在IgA肾病间质纤维化中的意义

Th1/Th2 and Th17/Treg balance status of CD4+T cells in interstitial fibrosis of IgA nephropathy

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