ISSN 1006-298X      CN 32-1425/R

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肾脏病与透析肾移植杂志 ›› 2024, Vol. 33 ›› Issue (2): 101-107.DOI: 10.3969/j.issn.1006-298X.2024.02.001

• 论著 •    下一篇

糖尿病与非糖尿病血液透析患者心脏自主神经的功能变化

  

  • 出版日期:2024-04-28 发布日期:2024-04-23

Functional changes of Cardiac autonomic nervous system on hemodialysis patients with or without diabetes

  • Online:2024-04-28 Published:2024-04-23

摘要: 目的:通过分析血液透析(HD)开始至透析后24 h(共28 h)的心率变异性(HRV),探究糖尿病与非糖尿病的维持性血液透析(MHD)患者不同时段心脏自主神经功能的差异及变化,为改善患者心脏事件的发生提供依据。
方法:选取2021-10-01~2022-12-31在北京大学人民医院HD中心行MHD的患者,心电记录在HD开始时采集,持续至少28 h。比较两组患者在HD开始后1 h、2 h、3 h、4 h、5 h、28 h的HRV参数。
结果:共纳入MHD患者110例,其中糖尿病患者36例(32.73%)。糖尿病组冠心病比例较高、透析龄较短、单室尿素清除指数(spKt/V)较低。在透析过程中糖尿病组全部窦性心搏RR间期的标准差(SDNN)和低频(LF)持续低于非糖尿病患者(P<0.05),非糖尿病患者RR间期差值的均方根(RMSSD)呈逐渐升高趋势,两组在HD开始1 h后出现明显差异。HD间期, 糖尿病患者透析后1 h SDNN及LF明显高于非糖尿病患者,HD后24 h两组间各心率变异性参数无统计学差异。非糖尿病患者HD后24 h HRV明显下降。
结论:糖尿病对MHD患者的心脏自主神经功能影响超过了尿毒症背景。非糖尿病MHD患者心脏自主神经功能优于糖尿病患者。


关键词: 血液透析, 糖尿病, 心率变异性, 心脏自主神经功能障碍

Abstract: Objective:To evaluate the impact of diabetes among hemodialysis patients with the analysis of intradialytic and interdialytic heart rate variability.
Methodology:This study was carried out in the Hemodialysis Center of Peking University People’s Hospital between October 1, 2021 and December 31, 2022. HRV were measured at the beginning of hemodialysis, lasted for 28 hours or above. We compared heart rate variability of each hour (1h, 2h, 3h, 4h, 5h, 28h) between diabetic and non-diabetic groups.
Results:One hundred and ten patients were enrolled, included 36 diabetic patients (32.73%). Diabetic HD patients had higher proportion of coronary artery disease, shorter dialysis vintage and lower spKt/V. Intradialytic HRV showed that diabetic patients had lower SDNN and LF than non-diabetic patients(P<0.05). RMSSD of diabetic HD patients decreased throughout the HD process, non-diabetic patients increased gradually, neither changes reached significant level. RMSSD was significantly different between diabetic and non-diabetic groups after first hour of HD. Diabetic group had significantly lower SDNN-5 and LF-5. Diabetes was not associated with differences in any HRV-28 parameter. SDNN-28、RMSSD-28、LF-28、HRV-28 decreased dramatically in non-diabetic patients.
Conclusion:The impact of diabetic outstood the influence of uremic autonomic dysfunction in maintenance hemodialysis patients. Cardiac autonomic function of non-diabetic HD patients obviously compensated.


Key words: hemodialysis, diabetes, heart rate variability, cardiac autonomic dysfunction