关键词: 小檗碱, 代谢综合征, 内质网应激, 肾损害

Abstract:

Ｏｂｊｅｃｔｉｖｅ：To observe the effects of berberine on urinary inositolrequiring enzyme (IRE1),xbox binding protein1 (XBP1),caspase12 mRNA and the expression of IRE1,XBP1,caspase12 in blood and urine of patients with metabolic syndrome and renal damage,and to explore the metabolism of berberine from endoplasmic reticulum stress mechanism.
Ｍｅｔｈｏｄｏｌｏｇｙ：20 patients with metabolic syndrome and renal damage were randomly divided into control group(n=10),treatment group (n=10).Basic treatments of metabolic syndrome were given to patients in group A.Berberine were prescribed to patients in group B addition to basic treatments.Patients were observed for 8 weeks .At the same time,10 healthy people with gender and age matched were selected as healthy group (n=10).
Ｒｅｓｕｌｔｓ：After 8 weeks of treatment,the body mass ind(BMI),FBG,2hPBG,triglyceride(TG),low density lipoprotein chesterol(LDLC),and fasting insulin(FINS) levels in the treatment group were lower than those in the control group (P<005),and the treatment group was superior to the control group (P<005).After 8 weeks of treatment,the expressions of urinary IRE1,XBP1,caspase12 mRNA,urine and blood IRE1,XBP1 and caspase12 protein in the treatment group were lower than those in the control group (P<005),and its expression decreased further with the prolongation of treatment time (P<005) in treatment group.
Ｃｏｎｃｌｕｓｉｏｎ：Berberine can improve insulin resistance，regulate glucose and lipid metabolism disorders in patients with metabolic syndrome conbined with renal damage,and reduce the expression of urinary IRE1,XBP1,caspase12 mRNA,blood and urine IRE1,XBP1,caspase12 proteins.The mechanism may be related to berberine inhibiting the excessive activation of the IRE1XBP1 pathway in endoplasmic reticulum stress.

Key words: berberine, metabolic syndrome, endoplasmic reticulum stress, renal damage