关键词: C3肾小球肾炎, 吗替麦考酚酯, 泼尼松, 治疗

Abstract:

Ｏｂｊｅｃｔｉｖｅ：To evaluate the therapeutic efficacy of prednisone with mycophenolate mofetil (Pred+MMF) and prednisone (Pred) alone in patients with C3 glomerulonephritis(C3GN).
Ｍｅｔｈｏｄｏｌｏｇｙ：we conducted a retrospective analysis of patients with C3GN confirmed by renal biopsy,8 patients received Pred+MMF treatment,19 patients received Pred treatment.We compared remission and prognosis of two groups.
Ｒｅｓｕｌｔｓ：(1) there were 3 males and 5 females with median age of 19 (16～27) years old in Pred+MMF group.11 males and 8 females were treated with Pred alone,with the median age of 33 (19～45) years old.There were no significant differences in baseline clinical data and histomorphological features between the two groups.(2) The median followup time was 435% in the Pred+MMF group,and the renal remission rate was 375%.One patient reached the primary endpoint.The median followup time in the Pred group was 415 months.The renal remission rate was 529%,and 2 patients reached the primary endpoint.There was no significant difference in renal remission rate and prognosis between the two groups.(3) 1/11 patients were positive for C3Nef.Three patients underwent genetic testing,none of them with genetic variants in complement genes (4) There were few adverse reactions of immunosuppressive agents,and one patient in each group had infection.
Ｃｏｎｃｌｕｓｉｏｎ：Pred+MMF is effective in the treatment of some C3GN,but the curative effect is not better than prednisone regimen alone.

Key words: C3 glomerulonephritis, mycophenolate mofetil, prednisone, treatment