关键词: 草酸性肾病, 病因, 急性肾损伤, 预后

Abstract:

Ｏｂｊｅｃｔｉｖｅ：To investigate the etiology,clinicopathological features,treatment and prognosis of oxalate nephropathy（OxN）.
Ｍｅｔｈｏｄｏｌｏｇｙ：A retrospective analysis of patients diagnosed as OxN by renal biopsy from January 2013 to April 2018 in Jinling Hospital was performed.The etiology and clinicopathological characteristics of the patients were analyzed.
Ｒｅｓｕｌｔｓ：A total of 52 cases of OxN were collected,including 39 males and 13 females.The average age was 494±123 years.Two cases were primary hyperoxaluria and 50 cases were secondary OxN.The most common cause was medication,following by ingestion of foods rich in oxalate and poisoning.The most frequent chief complains were oliguria/anuria (500%).In native kidney,AKI stage 1,2,3 and AKI on CKD (ACKD) accounted for 41%,82%,673%,and 204%,respectively.The highest serum creatinine (SCr) during hospitalization was （7832±4252） μmol/L.Urinary oxalate excretion increased in all 9 cases detection with average of (9035±3514) mg/24h.Kidney biopsy showed extensive calcium oxalate crystal deposition with acute tubulointerstitial nephritis.Twentyseven patients (519%) received continuous renal replacement therapy.At the end of followup of (121±156) months,2 patients reached ESRDIn 33 of 41 (805%) patients who followed up for >3 months,renal function returned to normal in 56±39 days.
Ｃｏｎｃｌｕｓｉｏｎ：
OxN is associated with a cluster of etiologies and manifestations as AKI or ACKD.Half of the patients required renal replacement therapy.Most of the patients had renal function recovery.

Key words: oxalate nephropathy, etiology, acute kidney injuryprognosis