ISSN 1006-298X      CN 32-1425/R

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肾脏病与透析肾移植杂志 ›› 2014, Vol. 23 ›› Issue (1): 36-41.

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营养评估法对老年维持性血液透析患者死亡的预测

  

  • 出版日期:2014-02-28 发布日期:2014-02-25

Predictive ability of nutritional assessment on the mortality of elderly hemodialysis patients

  • Online:2014-02-28 Published:2014-02-25

摘要:

【摘要】目的:分析并比较不同营养评估法对老年维持性血液透析(maintenance hemodialysis MHD)患者死亡的预测作用。方法:纳入2010年6月前已进行维持性血液透析3月以上,年龄≥60岁的患者60名,收集一般资料,对其进行问卷调查,体测量,及生化指标检测,分别计算主观全面营养评估(subjective global assessment SGA),营养不良—炎症评分(malnutrition inflammation score MIS)及微型营养评估简表(mini nutrition assessment short form MNA-SF)评分。前瞻性随访至2013年6月,以患者死亡或试验结束为研究终点。Kaplan-meier法及COX回归分析不同营养评估方法对患者死亡的预测作用。结果:Kaplan-meier生存分析提示,分别以SGA评分法及MNA-SF评分法分组,营养不良患者组死亡率均明显高于营养良好组患者(p=0.008,p=0.029);而以MIS评分法分组,两组患者死亡率没有差异。COX回归分析提示校正年龄,kt/v,合并心血管疾病,血磷,PTH及钙化等因素后,SGA评分结果对患者死亡有独立的预测作用(OR=8.877,p=0.045)。但MNA-SF评分结果与患者死亡无独立相关性。结论:SGA评分法对老年维持性血液透析患者死亡的预测作用优于MIS法及MNA-SF法。对于老年维持性血液透析患者的营养评估,SGA可能是更为合适的整体营养评估方法。

关键词: 维持性血液透析, 营养评估, 死亡

Abstract:

【Abstract】Objective: To compare the predictive ability of the different methods of nutritional assessment on the mortality of elderly hemodialysis patients. Methodology: Sixty patients, who were treated with MHD for more than 3 months at Jun 2010 and aged ≥60 years, were included in this study. SGA, MIS and MNA were used to assess the nutrition in the elderly patients with MHD. They were divided into malnutrition and good nutrition group according to the SGA or MNA-SF and followed up for 36 months. Death or end of the trail was the endpoint of study. Kaplan-Meier and Cox proportional hazard regressions were used to determine the predictive ability of the three methods of nutritional assessment on the mortality of the patients. Results: Kaplan-meier survival analysis showed that the mortality in the malnutrition group was higher than that in the good nutrition group. When grouping was done according to the MIS, there was no different in mortality between malnutrition and good nutrition group. COX regression analysis adjusted for age, kt / v, cardiovascular disease, phosphorus, PTH and calcifacation and other factors, result of SGA was the independent predictor of the death of the patients (OR = 8.877, p = 0.045). But result of MNA-SF had no independent correlation with the death of patients. Conclusion: The predictive ability of SGA on the mortality of the elderly MHD patients is precede of the MIS and the MNA-SF. SGA as overall nutritional assessment method may be more appropriate for elderly MHD patients nutritional assessment.

Key words: maintenance hemodialysis,  nutrition assessment , mortality