关键词: 干燥综合征, 肾脏损伤, 预后

Abstract:

Absrtact Objective: To analyze long-term prognosis and the factors affecting the prognosis in primary Sjogren's syndrome with renal damage. Methodology: A retrospective analysis was made in seventy cases of primary Sjogren's syndrome with renal damage. Their clinical manifestations, immunological indicators, pathologic features, treatment protocols, long-term prognosis and the factors affecting the prognosis were investigated. Results: They were 73 females and 2 males with onsetting age of 7 to 68 years old (median of 39). Sjogren's syndrome renal damage was given priority to tubular interstitiallesion. Renal biopsy confirmed that interstitial nephritis occupied 98.5%. 1/3 of patients took a large number of immunosuppressive agents. The time of followe-up was 62.8 ± 35.6 months (median of 54). The long-term complications were kidney stone, neuropsychiatric symptoms and hematological malignancy. At the end of the follow-up, 2 patients’ serum creatinine multiplied (more than 1.24 mg/dl), one reached ESRD and no one died. 5-year survival rate both of human and kidney was 100%, while 10-year survival rate of human and kidney was 100% and 98.7%, respectively. The factors associated with prognosis included the chronic degree of the tubular interstitiallesion (P=0.001), the lvevl of serum globulin (P=0.018), serum IgG (P=0.042) and hemoglobin (P=0.049). Conclusion: The long-term prognosis of primary Sjogren's syndrome patients with renal damages was good. The main factors affecting long-term prognosis included the chronic degree of the tubular interstitial lesion, hyperglobulinemia, high serum IgG level and anemia.

Key words: Sjogren's syndrome,  renal damage, prognosis