Abstract:

ABSTRACT Objective：To compare effect and safety between tacrolimus and cyclosporine in adult renal transplant receipts for 5 years follow up. Methodology：Between Mar 2005 and Mar 2009, a total of one hundred eighty seven adult renal transplant receipts were selected into this retrospective study. They were divided into two groups according to the using different kinds of CNI: group TAC (n=120) and group CsA (n=67）. The time of follow-up was 5 years. The incidence of crossovers, hirsutism, gingival hyperplasia, neurological complication, refection, hypertention, and diabetes were observed in two groups,. The levels of blood pressue (systolic and diastolic pressure), serum levels of TC, TG, and LDL were also detected in two groups. The value of eGFR and 5-year survival rate of patient/graft were compared between two groups. Results：The incidence of diabetes（35.8% vs 19.4%，P<0.05） and neurological complication（15% vs 4.5%，P<0.05） in group TAC was significantly higher than that in group CsA. The incidence of crossovers（11.6% vs 23.9%，P<0.05）, hirsutism（3.3% vs 11.9%，P<0.05）, hyperlipemia（36.7% vs 64.2%，P<0.05），and hypertention（72.6% vs 87.3%，P<0.05）were markedly lower than those in group CsA. The value of diastolic pressure（80.3±13.5mmHg Vs 85.1±15.7mmHg，P<0.05）, level of TC（3.85±2.36 vs 4.73±2.71，P<0.05）, and level of LDL（2.74±2.04 vs 3.36±1.97，P<0.05） in group TAC were significantly lower than those in Group CsA. The value of eGFR in group TAC were markedly higher than that in Group CsA（92.5±28.8 ml/min vs 89.7±33.1 ml/min，P<0.05）. Conclusion：There are some difference in effect and safety between tacrolimus and cyclosporine. CNI shoud be used individualizedly in transplant receipts.

Key words: Tacrolimus, Cyclosporine, Kidney transplantation, Treatment outcome, Complication