Abstract:

ABSTRACT Objective: To analyze the cause of hospitalization and the clinical characteristics of focal segmental glomerulosclerosis（FSGS）patients in the renal intensive care unit (RICU).  Methodology: Forty eight patients with FSGS, who addmitted to the RICU from July 2009 to December 2012, were enrolled in this retrospective study. Their clinical characteristic, treatment regimens and complications were investigated.  Results: A total of 48 patients with FSGS was accounted for 2.93% of all patients hospitalized in RICU (1626 cases), and 31.4% of all patients with nephrotic syndrome（NS） (total 153 NS). The infections, acute kidney injury and electrolyte disturbances were the main causes hospitalized in RICU  Using steroids or immune inhibitors increased the incidence of infection.  Among 31 patients with AKI, there were 12 of co-infection, 19 of low blood volume, and 4 of clear using the renal toxicity of drugs.  Conclusion: The infections, AKI, and electrolyte disorders weres the leading causes of patients with FSGS   hospitalized in ICU patients with FSGS. Infection closely associated with the use of the steroids and immune inhibitors. The low blood volume and some drugs（including statins、rheomacrodex and chinese herble medicine）were the major causes of AKI.

Key words:  focal segmental glomerulosclerosis,  , Renal intensive care unit,  , infection,  , acute kidney injury,  , electrolyte disorder,  , Steroid