Abstract:

 Objective: To investigate the long-term renal outcome and prognostic factors of adult endocapillary proliferative glomerulonephritis.  Methodology: A total of 62 adult patients, who diagnosed as endocapillary proliferative glomerulonephritis by renal biopsy, were enrolled in this study. They were divided into two groups: streptococcal group (n=43) and non-streptococcal group (n=19). The clinical and pathological features were summarized. For the purpose of outcome analysis, 47 patients with a follow-up of ≥12 months were included. The univariate and multivariate analyses were performed for prognostic factors.  Results: Proteinuria and hematuria were both more severe in non-streptococcal group. There were no significant differences on light microscopy between 2 groups. Among the 47 patients with ≥ 12 months of follow-up, the complete remission rate was 89.4% and the incidences of chronic renal failure and ESRD were 4.3% and 2.1%. The univariate analysis showed that the prognostic factors were age, underlying disease, tubular damage and C1q staining respectively. On multivariate analysis, underlying disease and proteinuria were significant and independent inverse correlate of complete remission.  Conclusion: The long-term prognosis of adult endocapillary proliferative glomerulonephritis is optimistic. Proteinuria and underlying disease are important prognostic factors.

Key words: adults , endocapillary proliferative glomerulonephritis , prognosis