ISSN 1006-298X      CN 32-1425/R

Chinese Journal of Nephrology, Dialysis & Transplantation

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Long-term prognosis and risk factors of peritoneal dialysis patients:a cohort of 245 patients

  

  • Online:2019-10-28 Published:2020-01-07

Abstract:

Objective:To analyze the clinical features,outcomes and risk factors of peritoneal dialysis (PD) patients in our hospital.
Methodology:Clinical data of 245 PD patients treated in our hospital from Jan 2008 to Dec 2018 were collected,the patients survival rate,technical survival rate time on therapy(TOT) and drop out rate (DOR) were analyzed.According to the outcome,patients were divided into death group and survival group,and the characteristics between the two groups were compared.
Results:155(633%) were males, the mean age at the beginning of PD was (563±144) years, and the mean PD duration was (233±188) months.Chronic glomerulonephritis (669%) was the most common primary disease, followed by diabetes mellitus(241%).Up to Dec 2018,the patients remained on PD in 124 cases(506%),64 cases(261%) died,changed to hemodialysis(HD) in 25 cases(102%),treated with kidney transplant in 19 cases(78%),combination theraphy with PD and HD in 9 cases(37%),and dropped out of our followup in 4 cases(16%).TOT increased gradually with year and was 254 months in 2018.DOR decreased gradually and was 259% in 2018.The main cause of death was cardiovascular events (531%), followed by cerebrovascular events (234%) and infection (187%). Compared to the survivals, patients in the mortality group seemed to have greater popularity of diabetes, but lower levels of albumin, prealbumin, serum creatinine, β2MG and phosphorus, and were much more older.The patient survival rates at 1,3,5years were 890%、677%、566%,respectively,technique survival rates at 1,3,5years were 907%、811%、644%.The predictors of patients death in this study were age(OR 1199,95%CI 1093~1316,P=0000),serum creatine(OR 1004,95%CI 1000~1008,P=0030)  and  prealbumin(OR 0986,95%CI 0975~0998,P=0021).
Conclusion:The major cause of dropout from PD was death,followed by the transfer to hemodialysis.Cardiovascular event was the most important cause of death,and peritonitis was the major reason for the change from PD to HD.Patients with older age, hypoprealbuminemia and diabetes were associated with poor outcomes.