Abstract:

Lupus nephritis(LN)is one of the most common and severe complication of systemic lupus erythematosus(SLE).Up to 20 percent of LN patients will progress to end stage renal disease(ESRD)within 10 years after their diagnosis,which brings substantial health burden to the patients.With new therapeutic options emerging in the management of LN in recent decades,therapeutic efficacy and patient survival have been improved.However,whether these advances have impacted longterm renal survival is unclear.One research from America found that the rates of endstage LN stopped increasing between 1995 and 2010 and declined in the last decade.Research from China observed that renal outcome improved from 1994 to 2010This review discusses recent data on the changes in epidemiology of patients with LN,especially on the trends in outcomes.

Key words: lupus nephritis, outcome, end stage renal disease