Abstract: Ｏｂｊｅｃｔｉｖｅ：Analyze the clinicopathological features, treatment strategy, and outcomes of patients suffering from DMO poisoning.
Ｍｅｔｈｏｄｏｌｏｇｙ：This study presented three cases of nephropathy associated with DMO poisoning at our center. Additionally, a literature review was conducted to summarize the clinicopathological features, treatment strategies, and outcomes of acute DMO poisoning.
Ｒｅｓｕｌｔｓ：Three male patients developed severe acute kidney injury (AKI) subsequent to DMO exposure. Renal biopsy confirmed the diagnosis of acute oxalate nephropathy. Following treatment strategies that included hemodialysis, adequate hydration, and anti-inflammatory agents, all patients exhibited improvement in renal function. A literature review of 21 reported cases of DMO poisoning, uia dermal contact or respiratory exposure, revealed that 95.2％ exhibited varying degrees of elevated serum creatinine levels, and 52.4％ were identified with AKI stage 3. 61.9％ of the patients underwent hemodialysis, while 23.8％ were treated with glucocorticoids. 9.5％ of the patients succumbed to multiple organ failure, whereas 71.4％ achieved normal renal function.
Ｃｏｎｃｌｕｓｉｏｎ：DMO poisoning is characterized by acute kidney injury, with oxalate crystals observed in renal pathological findings. Therapeutic interventions such as hemodialysis, hydration, citrate solutions, and low-dose glucocorticoids may offer clinical benefits post-intoxication. The majority of the patients experienced a recovery of kidney function.

Key words: oxalate nephropathy, acute kidney injury, dimethyl oxalate, toxic nephropathy